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Abbreviations used: Aβ amyloid beta AD Alzheimer disease Akt protein kinase B AP-1 activator protein 1 ApoE −/− apolipoprotein E-deficient mice ARE antioxidant response element ASK1 apoptosis signal-regulating kinase 1 BH 4 tetrahydrobiopterin CAD coronary artery disease CBS +/− mice heterozygous deficient for cystathionine beta-synthase ERK1/2 extracellular signal-regulated kinase 1/2 eNOS endothelial nitric oxide synthase FAK focal adhesion kinase GPx1 glutathione peroxidase 1 GPx1 +/+ GPx1 wild type mice GPx1 −/− homozygous GPx1 knockout mice GPx1 +/− heterozygous GPx1 knockout mice GSH reduced glutathione GSSG oxidized glutathione ICAM1 intercellular adhesion molecule 1 I/R ischemia reperfusion JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH-associated protein 1 MAPK mitogen-activated protein kinase MCAO middle cerebral artery occlusion mcm 5 U 5-methoxy-carbonylmethyluridine mcm 5 Um 5-methoxy-carbonylmethyl-2’- O -methyluridine MCSF macrophage colony stimulating factor NFκB nuclear factor kappa B NMDA N-methyl-D-aspartate NOX1 NADPH oxidase 1 NOX2 NADPH oxidase 2 NOX4 NADPH oxidase 4 Nrf2 nuclear factor erythroid 2-related factor 2 OTC L-2-oxothiazolidine-4-carboxylic acid oxLDL oxidized low-density lipoproteins PGC1α peroxisome proliferator-activated receptor-γ-coactivator 1α PI3K phosphatidylinositol 3-kinase PKC βII protein kinase C beta II ROS reactive oxygen species ROS1 ROS proto-oncogene 1, receptor tyrosine kinase SBP2 SECIS binding protein 2 Sec selenocysteine SECIS selenocysteine incorporation sequence SHP-2 SH2 domain-containing protein tyrosine phosphatase-2 TNFα tumor necrosis factor alpha TRAF tumor necrosis factor receptor-associated factor VCAM1 vascular cell adhesion molecule 1 Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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Unpaired two-tailed t test was then performed and plotted: t = 0.3158, df=6, P ns = 0.7629